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KMID : 0370219880320050340
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Yakhak Hoeji
1988 Volume.32 No. 5 p.340 ~ p.342
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Synthesis of Ibuprofen
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Abstract
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New synthetic method for ibuprofen, which is a potent antiinflammat° ry agent, was described. Ethyl a-methylthio-p-isobutylphenylacetate was obtained from Friedel-Crafts reaction of isobutylbenzene with ethyl a-chloro-a-(methylthio)acetate in the presence of SnC14. Ibuprofen was prepared in good yield by treatment of ethyl a-methylthio-p-isobutylphenylacetate with NaH and Mel, followed by desulfurization with zinc dust-acetic acid and hydrolysis of the resultant ethyl 2-methylthio-2-(4-isobutylphenyl)propionate.
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